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Glossary for Neuronal Migration Disorders

  • Agenesis of the corpus callosum: Congenital absence of connective part of the brain.
  • Agyria: A condition which is characterized by the malformation or absence of the convolutions of the cerebral cortex
  • Brain conditions: Medical conditions that affect the brain
  • Congenital conditions: Any condition that you are born with such as birth defects or genetic diseases.
  • Congenital conditions -- physical defects: Congenital (birth) defects causing a physical structure defect (rather than metabolic).
  • Developmental problems: Physical or mental development difficulty.
  • Failure to thrive: Slow growth or inadequate weight gain of an infant or child.
  • Head Conditions: Conditions that affect the head
  • Lissencephaly: A very rare disorder characterized by abnormal brain formation so that the brain surface appears smooth rather than convoluted.
  • Macrogyria: A condition characterized by a moderate reduction in the sulci number of the brain
  • Mental retardation: A very rare syndrome characterized mainly by mental retardation, hypogonadism, diabetes and facial and skull abnormalities.
  • Muscle weakness: A condition which is characterized by an inability of the muscles to function at their full strenght
  • Nervous system conditions: Diseases affecting the nerves and the nervous system.
  • Pachygyria: A condition which is characterized by the presence of thick convolutions of the cerebral cortex
  • Poor feeding: Poor feeding (mostly in infants)
  • Porencephaly: A central nervous system disorder involving cysts in the brain cortex caused by stroke, infection or genetic anomaly.
  • Schizencephaly: A very rare disorder where the brain fails to develop normally and slits or clefts form in the brain. They type and severity of symptoms is determined by the degree of abnormality.
  • Seizures: A rare syndrome characterized by mental retardation, seizures and high levels of hydroxylysine in the urine.


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