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COX-2 inhibitors and heart attack risk

Researchers from the University of Pennsylvania School of Medicine have found that Vioxx poses a greater heart attack risk than Celebrex but neither of them showed a significant increase in risk of heart attack when compared to people not using the drugs. They found that NSAIDs (nonsteroidal anti-inflammatory drugs such as aspirin, ibuprofen and naxproxen) posed a lower heart attack risk than COX-2 inhibitors. Vioxx's higher risk was probably due to factors such as blood pressure, endothelial function and oxidative stress. Researchers suggest that results indicating that Celebrex reduced heart attack risk compared to NSAIDs are not necessarily conclusive. Further detailed trials are needed to confirm all of the above results.

Source: summary of medical news story as reported by Science Daily

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About: COX-2 inhibitors and heart attack risk

Date: 15 December 2004

Source: Science Daily


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