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It is believed that abnormal serotonin levels in the brain may be a factor in major depression and other neuropsychiatric disorders. Researchers have found a genetic defect which may cause these abnormal levels. Depression sufferers with this gene abnormality are unlikely to respond to SSRI treatment and use of these drugs may even be the reason why some are more prone to suicidal behavior and increased mania and psychosis. Thus this discovery may have an application in determining a successful depression treatment. Larger studies are needed to confirm this discovery but it certainly gives a new direction in depression diagnosis and treatment.
Source: summary of medical news story as reported by Pharma Live
About: Recently discovered gene defect may be the cause of some types of depression
Date: 9 December 2004
Source: Pharma Live
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