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Causes of Pelizaeus-Merzbacher Disease

Causes of Pelizaeus-Merzbacher Disease

Pelizaeus-Merzbacher disease is caused by a mutation in the proteolipid protein 1 gene, PLP1, which is required for normal myelin formation. A small number of people with Pelizaeus-Merzbacher disease do not have a mutation in this gene, suggesting that mutations in another gene(s) may also cause Pelizaeus-Merzbacher disease.

Pelizaeus-Merzbacher Disease: Related Medical Conditions

To research the causes of Pelizaeus-Merzbacher Disease, consider researching the causes of these these diseases that may be similar, or associated with Pelizaeus-Merzbacher Disease:

Pelizaeus-Merzbacher Disease: Causes and Types

Causes of Types of Pelizaeus-Merzbacher Disease: Review the cause informationfor the various types of Pelizaeus-Merzbacher Disease:

  • Classic Pelizaeus-Merzbacher Disease
  • Adult Pelizaeus-Merzbacher Disease
  • more types...»

Causes of Broader Categories of Pelizaeus-Merzbacher Disease: Review the causal information about the various more general categories of medical conditions:

What causes Pelizaeus-Merzbacher Disease?

Causes: Pelizaeus-Merzbacher Disease: It is usually caused by a mutation of the gene that codes for a myelin protein called proteolipid protein or PLP. (Source: excerpt from NINDS Pelizaeus-Merzbacher Disease Information Page: NINDS)

Related information on causes of Pelizaeus-Merzbacher Disease:

As with all medical conditions, there may be many causal factors. Further relevant information on causes of Pelizaeus-Merzbacher Disease may be found in:


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