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Pick's Disease

Pick's Disease: Introduction

Pick's disease is a type of frontotemporal dementia, which causes shrinkage degeneration of the nerve cells of temporal and frontal lobes or areas of the brain. In Pick's disease, there is excessive build-up of protein in the brain cells. This causes shrinkage degeneration of the nerve cells of temporal and frontal lobes or areas of the brain. These areas of the brain are important to decision-making, language, emotion, personality, and behavior control.

Pick's disease is a seriously disabling neurodegenerative disease of the brain that results in a progressive and permanent loss of cognitive and mental performance. The underlying cause of Pick's disease is unknown, but there may be a genetic component to its development. Risk factors are unknown.

Pick's disease is a rare form of dementia and is far less common than some other types of dementia, such as Alzheimer's disease and vascular dementia. Symptoms of Pick's disease generally begin in the fourth through sixth decade of life and are progressive. Pick's disease occurs more often in women than in men. The rate of development of symptoms is generally gradual but varies somewhat between individuals. Personality changes are often the first symptom of Pick's disease. Symptoms can affect personality, behavior, language, memory, emotion, and may also affect muscles. For more details on symptoms and complications, refer to symptoms of Pick's disease.

There is no specific diagnostic test that can detect Pick's disease. Making a diagnosis is based on symptoms and includes performing a variety of tests and assessments that evaluate the brain and can rule out other causes of symptoms, such as vascular dementia, depression, and other psychiatric disorders. Diagnosis and treatment may require the collaboration of a variety of providers, including a primary care physician, neurologist, psychiatrist, and/or psychologist.

The diagnostic process begins with taking a thorough personal and family history, including symptoms, and completing a physical examination. This includes a neurological exam. A neurological exam evaluates the nerves and nervous system and such functions as alertness, orientation, reflexes, sensation, movement, balance, coordination, vision, and hearing.

Commonly used tests include a mini-mental state examination (MMSE), which evaluates mental function by assessing the answers provided to a series of questions. Imaging tests that are used in the diagnostic process include CT and MRI, which provide information about the structure of the brain. An EEG (electroencephalogram) may be performed to measure and record the electrical activity of the brain using sensors that are painlessly attached to the scalp. An EEG can detect abnormal patterns of electrical activity that may be present in dementia.

It is possible that a diagnosis of Pick's disease can be missed or delayed because symptoms develop gradually and are similar to symptoms of other diseases and conditions. For more information about diseases and conditions that can mimic Pick's disease, refer to misdiagnosis of Pick's disease.

Pick's disease is not curable, and at this time there are no treatments that can slow the advancement of the disease. However, there are some medications and therapies that may help to reduce some symptoms and maximize independence and the quality of life. For more information on treatment, refer to treatment of Pick's disease. ...more »

Pick's Disease: Pick's disease is a form of dementia characterized by a slowly progressive deterioration of social skills and changes in personality, along ... more about Pick's Disease.

Pick's Disease: Degenerative dementia condition. More detailed information about the symptoms, causes, and treatments of Pick's Disease is available below.

Pick's Disease: Symptoms

Symptoms of Pick's disease can affect decision-making, language, emotion, personality, and behavior control. Symptoms of Pick's disease are very similar to symptoms of other types of dementia, especially Alzheimer's disease. However, in Pick's disease memory loss and mental impairment tends to occur later than they do in the development of Alzheimer's ...more symptoms »

Pick's Disease: Treatments

There are currently no treatments that can cure or stop the progression of Pick's disease. The care of people with Pick's disease is aimed at minimizing symptoms and maximizing independence and the quality of life as much as possible.

There are some medications that may help to manage some symptoms, and there are clinical trials taking place to ...more treatments »

Pick's Disease: Misdiagnosis

A diagnosis of Pick's disease may be delayed or missed because early symptoms may develop gradually and or may be associated with the normal aging process. In addition, symptoms of Pick's disease can mimic symptoms of a variety of diseases, disorders or conditions. These include obsessive compulsive disorder, Alzheimer's disease, vascular dementia, Creutzfeldt-Jacob disease, ...more misdiagnosis »

Symptoms of Pick's Disease

Treatments for Pick's Disease

Home Diagnostic Testing

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Wrongly Diagnosed with Pick's Disease?

Pick's Disease: Related Patient Stories

Causes of Pick's Disease

Read more about causes of Pick's Disease.

Disease Topics Related To Pick's Disease

Research the causes of these diseases that are similar to, or related to, Pick's Disease:

Pick's Disease: Undiagnosed Conditions

Commonly undiagnosed diseases in related medical categories:

Misdiagnosis and Pick's Disease

Undiagnosed stroke leads to misdiagnosed aphasia: BBC News UK reported on a man who had been institutionalized and treated for mental illness because he suffered from more »

Alzheimer's disease over-diagnosed: The well-known disease of Alzheimer's disease is often over-diagnosed. Patients tend to assume that any memory loss or forgetulness symptom might be Alzheimer's, whereas there are many more »

Dementia may be a drug interaction: A common scenario in aged care is for a patient to show mental decline to dementia. Whereas this can, of course, more »

Tremor need not be Parkinson's disease: There is the tendency to believe that any tremor symptom, or shakiness, means Parkinson's disease. The reality is that there are more »

Mild traumatic brain injury often remains undiagnosed: Although the symptoms of severe brain injury are hard to miss, it is less clear for milder injuries, or even more »

ADHD under-diagnosed in adults: Although the over-diagnoses of ADHD in children is a well-known controversy, the reverse side related to adults. Some adults more »

MTBI misdiagnosed as balance problem: When a person has symptoms such as vertigo or dizziness, a diagnosis of brain injury may go overlooked. This is particularly true of mild traumatic brain injury (MTBI), more »

Rare diseases misdiagnosed as Parkinson's disease: A rare genetic disorder is often misdiagnosed as Parkinson's disease for men in their 50' more »

Bipolar disorder misdiagosed as various conditions by primary physicians: Bipolar disorder (manic-depressive disorder) often fails to be diagnosed correctly more »

Eating disorders under-diagnosed in men: The typical patient with an eating disorder is female. The result is that men with eating disorders often fail to be diagnosed or have a delayed diagnosis. See misdiagnosis of more »

Depression undiagnosed in teenagers: Serious bouts of depression can be undiagnosed in teenagers. The "normal" moodiness of teenagers can cause severe medical depression to be overlooked. See misdiagnosis of depression or more »

Brain pressure condition often misdiagnosed as dementia: A condition that results from an excessive pressure of CSF within the brain is often misdiagnosed. It may more »

Post-concussive brain injury often misdiagnosed: A study found that soldiers who had suffered a concussive injury in battle often were misdiagnosed on their return. A more »

Children with migraine often misdiagnosed: A migraine often fails to be correctly diagnosed in pediatric patients. These patients are not the typical migraine sufferers, but migraines can also occur in children. See more »

Undiagnosed anxiety disorders related to depression: Patients with depression (see symptoms of depression) may also have undiagnosed anxiety disorders (see symptoms of anxiety disorders). Failure to diagnose these more »

Vitamin B12 deficiency under-diagnosed: The condition of Vitamin B12 deficiency is a possible misdiagnosis of various conditions, such as multiple sclerosis (see more »

Pick's Disease: Research Doctors & Specialists

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Hospitals & Clinics: Pick's Disease

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Choosing the Best Hospital: More general information, not necessarily in relation to Pick's Disease, on hospital performance and surgical care quality:

Pick's Disease: Rare Types

Rare types of diseases and disorders in related medical categories:

Evidence Based Medicine Research for Pick's Disease

Medical research articles related to Pick's Disease include:

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Pick's Disease: Animations

Prognosis for Pick's Disease

Prognosis for Pick's Disease: Poor. Deterioration. Often death within 2-10 years.

Research about Pick's Disease

Visit our research pages for current research about Pick's Disease treatments.

Statistics for Pick's Disease

Pick's Disease: Broader Related Topics

Pick's Disease Message Boards

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User Interactive Forums

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Article Excerpts about Pick's Disease

Pick's disease is a form of dementia characterized by a slowly progressive deterioration of social skills and changes in personality, along with impairment of intellect, memory, and language. (Source: excerpt from NINDS Pick's Disease Information Page: NINDS)

Definitions of Pick's Disease:

A progressive form of presenile dementia found most often in middle-aged and elderly women and characterized by degeneration of the frontal and temporal lobes with loss of intellectual ability and transitory aphasia - (Source - WordNet 2.1)

Pick's Disease is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Pick's Disease, or a subtype of Pick's Disease, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)


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