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Diagnostic Tests for Pyrrolizidine Alkaloids Poisoning

Home Diagnostic Testing

These home medical tests may be relevant to Pyrrolizidine Alkaloids Poisoning:

Tests and diagnosis discussion for Pyrrolizidine Alkaloids Poisoning:

FDA Bad Bug Book (Excerpt)

Diagnosis of Human Illness: Evidence of toxicity may not become apparent until sometime after the alkaloid is ingested. The acute illness has been compared to the Budd-Chiari syndrome (thrombosis of hepatic veins, leading to liver enlargement, portal hypertension, and ascites). Early clinical signs include nausea and acute upper gastric pain, acute abdominal distension with prominent dilated veins on the abdominal wall, fever, and biochemical evidence of liver disfunction. Fever and jaundice may be present. In some cases the lungs are affected; pulmonary edema and pleural effusions have been observed. Lung damage may be prominent and has been fatal. Chronic illness from ingestion of small amounts of the alkaloids over a long period proceeds through fibrosis of the liver to cirrhosis, which is indistinguishable from cirrhosis of other etiology. (Source: FDA Bad Bug Book)

FDA Bad Bug Book (Excerpt)

Food Analysis: The pyrrolizidine alkaloids can be isolated from the suspect commodity by any of several standard alkaloid extraction procedures. The toxins are identified by thin layer chromatography. The pyrrolizidine ring is first oxidized to a pyrrole followed by spraying with Ehrlich reagent,whichgives a characteristic purple spot. Gas-liquid chromatographic and mass spectral methods also are available for identifying the alkaloids. (Source: FDA Bad Bug Book)


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