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Causes of Sjogren's Syndrome

Causes of Sjogren's Syndrome

Sjogren's syndrome is caused by autoimmunity to the tissues of the glands that produce tears and saliva. Environmental and genetic factors play a role in development of Sjogren syndrome. A significant risk factor for developing Sjogren syndrome is a pre-existing autoimmune connective tissue disorder, such as systemic lupus erythematosis and rheumatoid arthritis.

List of causes of Sjogren's Syndrome

Following is a list of causes or underlying conditions (see also Misdiagnosis of underlying causes of Sjogren's Syndrome) that could possibly cause Sjogren's Syndrome includes:

Causes of Sjogren's Syndrome (Diseases Database):

The follow list shows some of the possible medical causes of Sjogren's Syndrome that are listed by the Diseases Database:

Source: Diseases Database

Sjogren's Syndrome Causes: Male-Female Gender Ratio

Gender of Patients for Sjogren's Syndrome: Women 9:1, about 90% (NWHIC)....more »

Sjogren's Syndrome: Related Medical Conditions

To research the causes of Sjogren's Syndrome, consider researching the causes of these these diseases that may be similar, or associated with Sjogren's Syndrome:

Sjogren's Syndrome: Causes and Types

Causes of Types of Sjogren's Syndrome: Review the cause informationfor the various types of Sjogren's Syndrome:

Causes of Broader Categories of Sjogren's Syndrome: Review the causal information about the various more general categories of medical conditions:

Sjogren's Syndrome as a complication of other conditions:

Other conditions that might have Sjogren's Syndrome as a complication may, potentially, be an underlying cause of Sjogren's Syndrome. Our database lists the following as having Sjogren's Syndrome as a complication of that condition:

Sjogren's Syndrome as a symptom:

Conditions listing Sjogren's Syndrome as a symptom may also be potential underlying causes of Sjogren's Syndrome. Our database lists the following as having Sjogren's Syndrome as a symptom of that condition:

What causes Sjogren's Syndrome?

Causes: Sjogren's Syndrome: Autoimmune disorder primarily of saliva and tear glands.
Normally, the immune system works to protect us from disease by destroying harmful invading organisms like viruses and bacteria. In the case of Sjögren's syndrome, disease-fighting cells attack the glands that produce tears and saliva (the lacrimal and salivary glands). Damage to these glands keeps them from working properly and causes dry eyes and dry mouth. (Source: excerpt from Questions and Answers About Sjögren's Syndrome: NIAMS)
Article excerpts about the causes of Sjogren's Syndrome:
Researchers think Sjögren's syndrome is caused by a combination of genetic and environmental factors. Several different genes appear to be involved, but scientists are not certain exactly which ones are linked to the disease since different genes seem to play a role in different people. For example, there is one gene that predisposes Caucasians to the disease. Other genes are linked to Sjögren's in people of Japanese, Chinese, and African American descent. Simply having one of these genes will not cause a person to develop the disease, however. Some sort of trigger must activate the immune system.

Scientists think that the trigger may be a viral or bacterial infection. It might work like this: A person who has a Sjögren's-associated gene gets a viral infection. The virus stimulates the immune system to act, but the gene alters the attack, sending fighter cells (lymphocytes) to the eye and mouth glands. Once there, the lymphocytes attack healthy cells, causing the inflammation that damages the glands and keeps them from working properly. These fighter cells are supposed to die after their attack in a natural process called apoptosis, but in people with Sjögren's syndrome, they continue to attack, causing further damage. Scientists think that resistance to apoptosis may be genetic.

The possibility that the endocrine and nervous systems play a role is also under investigation. (Source: excerpt from Questions and Answers About Sjögren's Syndrome: NIAMS)

Medical news summaries relating to Sjogren's Syndrome:

The following medical news items are relevant to causes of Sjogren's Syndrome:

Related information on causes of Sjogren's Syndrome:

As with all medical conditions, there may be many causal factors. Further relevant information on causes of Sjogren's Syndrome may be found in:


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