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Stiff-Person Syndrome

Stiff-Person Syndrome: Introduction

A very rare autoimmune disorder of the central nervous system causing various symptoms, but also sometimes diabetes. The patient usually has anti-GAD antibodies, and about half get a type of secondary diabetes from SMS. ...more »

Symptoms of Stiff-Person Syndrome

Treatments for Stiff-Person Syndrome

Home Diagnostic Testing

Home medical testing related to Stiff-Person Syndrome:

Wrongly Diagnosed with Stiff-Person Syndrome?

Stiff-Person Syndrome: Related Patient Stories

Stiff-Person Syndrome: Complications

Review possible medical complications related to Stiff-Person Syndrome:

Causes of Stiff-Person Syndrome

Read more about causes of Stiff-Person Syndrome.

Disease Topics Related To Stiff-Person Syndrome

Research the causes of these diseases that are similar to, or related to, Stiff-Person Syndrome:

Stiff-Person Syndrome: Undiagnosed Conditions

Commonly undiagnosed diseases in related medical categories:

Misdiagnosis and Stiff-Person Syndrome

Leg cramps at night a classic sign: The symptom of having leg muscle cramps, particularly at night, is a classic sign of undiagnosed diabetes. However, there are also various other causes. See causes of leg cramps or more »

Vitamin B12 deficiency under-diagnosed: The condition of Vitamin B12 deficiency is a possible misdiagnosis of various conditions, such as multiple sclerosis (see symptoms of multiple sclerosis). See symptoms more »

Stiff-Person Syndrome: Research Doctors & Specialists

Research related physicians and medical specialists:

Other doctor, physician and specialist research services:

Evidence Based Medicine Research for Stiff-Person Syndrome

Medical research articles related to Stiff-Person Syndrome include:

Click here to find more evidence-based articles on the TRIP Database

Stiff-Person Syndrome: Animations

Prognosis for Stiff-Person Syndrome

Prognosis for Stiff-Person Syndrome: There is no cure for stiff-person syndrome. The long-term prognosis for individuals with stiff-person syndrome is uncertain. Management of the disorder with drug therapy may provide significant improvements and relief of symptoms. (Source: excerpt from NINDS Stiff-Person Syndrome Information Page: NINDS)

Research about Stiff-Person Syndrome

Visit our research pages for current research about Stiff-Person Syndrome treatments.

Clinical Trials for Stiff-Person Syndrome

The US based website lists information on both federally and privately supported clinical trials using human volunteers.

Some of the clinical trials listed on for Stiff-Person Syndrome include:

Statistics for Stiff-Person Syndrome

Stiff-Person Syndrome: Broader Related Topics

Stiff-Person Syndrome Message Boards

Related forums and medical stories:

User Interactive Forums

Read about other experiences, ask a question about Stiff-Person Syndrome, or answer someone else's question, on our message boards:

Article Excerpts about Stiff-Person Syndrome

Stiff-person syndrome is a rare progressive neurological disorder characterized by constant painful contractions and spasms of voluntary muscles, particularly the muscles of the back and upper legs. (Source: excerpt from NINDS Stiff-Person Syndrome Information Page: NINDS)

Definitions of Stiff-Person Syndrome:

A condition characterized by persistent spasms (SPASM) involving multiple muscles, primarily in the lower limbs and trunk. The illness tends to occur in the fourth to sixth decade of life, presenting with intermittent spasms that become continuous. Minor sensory stimuli, such as noise and light touch, precipitate severe spasms. Spasms do not occur during sleep and only rarely involve cranial muscles. Respiration may become impaired in advanced cases. (Adams et al., Principles of Neurology, 6th ed, p1492; Neurology 1998 Jul;51(1):85-93) - (Source - Diseases Database)

Stiff-Person Syndrome is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Stiff-Person Syndrome, or a subtype of Stiff-Person Syndrome, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)

Ophanet, a consortium of European partners, currently defines a condition rare when it affects 1 person per 2,000. They list Stiff-Person Syndrome as a "rare disease".
Source - Orphanet


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