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Diseases » Wolfram's disease » Wikipedia

Wolfram's disease in Wikipedia

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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Wolfram syndrome". (Source - Retrieved 2006-09-07 14:19:06 from


Wolfram syndrome, also called DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), is a rare genetic disorder, causing diabetes mellitus, optic atrophy, and deafness.

It was first diagnosed in 1938 by a physician named Wolfram in four siblings.

The disease affects both the brain (especially the brain stem) and the central nervous system.


It is thought to be caused by both a malfunction of the mitochondria and of myelination, the latter in effect similar to multiple sclerosis.


There is no known treatment.


Life expectancy of people suffering from this syndrome is about 30 years.

See also

  • List of rare diseases

 This disease article is a stub. You can help Wikipedia by expanding it.

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