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X-linked Genetic Diseases in Wikipedia

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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "X-linked dominant". (Source - Retrieved 2006-09-07 14:24:28 from


X-linked dominant is mode of inheritance in which a gene on the X chromosome is dominant$[1]$. Females are more frequently affected than males, although any X-linked dominant gene is not sex linked. The chance of passing on an X-linked dominant disorder differs between men and women.

This inheritance pattern is less common than X-linked recessive.


Females usually have two X chromosomes, while most males have one X and one Y chromosome. If a child has inherited the mutation from the X chromosome of one of their parents they will have the condition. A woman with an X-linked dominant disorder has a 50% chance of having an affected daughter or son with each pregnancy. The sons of a man with an X-linked dominant disorder will not be affected, but his daughters will all inherit the condition.

Some X-linked dominant conditions such as Aicardi Syndrome are fatal to boys, therefore only girls with these conditions survive. Similarly, individuals with Klinefelter's Syndrome are referred to as "47,XXY Males".

See also


  1. X-linked Dominant: Incontinentia pigmenti - Lucile Packard Children's Hospital

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