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What is Zollinger-Ellison syndrome?

What is Zollinger-Ellison syndrome?

  • Zollinger-Ellison syndrome: A rare disorder where excessive levels of the hormone gastrin are released into the stomach which increases stomach acidity which results in peptic ulcer development. A hormone secreting pancreatic or duodenal tumor is usually the cause.
  • Zollinger-Ellison syndrome: A gastrin-secreting tumor of the non-beta islet cells. It is usually located in the pancreas but is also found at other sites, as in the antrum of the stomach, hilus of the spleen, and regional lymph nodes. The presence of gastrinoma is one of three requirements to be met for identification of ZOLLINGER-ELLISON SYNDROME, which sometimes occurs in families with MULTIPLE ENDOCRINE NEOPLASIA TYPE 1 (MEN-1). Gastrinomas in patients with MEN-1 are usually diffuse in nature.
    Source - Diseases Database
  • Zollinger-Ellison syndrome: syndrome consisting of intractable peptic ulceration with gastric hypersecretion and hyperacidity.
    Source - WordNet 2.1

Zollinger-Ellison syndrome is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Zollinger-Ellison syndrome, or a subtype of Zollinger-Ellison syndrome, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)

Ophanet, a consortium of European partners, currently defines a condition rare when it affects 1 person per 2,000. They list Zollinger-Ellison syndrome as a "rare disease".
Source - Orphanet

Zollinger-Ellison syndrome: Introduction

Types of Zollinger-Ellison syndrome:

Broader types of Zollinger-Ellison syndrome:

How many people get Zollinger-Ellison syndrome?

Prevalance of Zollinger-Ellison syndrome: rare

Who gets Zollinger-Ellison syndrome?

Patient Profile for Zollinger-Ellison syndrome: Usually 30-60

Profile for Zollinger-Ellison syndrome: Zollinger-Ellison syndrome usually occurs in people between ages 30 and 60. (Source: excerpt from Zollinger-Ellison Syndrome: NIDDK)

How serious is Zollinger-Ellison syndrome?

Complications of Zollinger-Ellison syndrome: see complications of Zollinger-Ellison syndrome

What causes Zollinger-Ellison syndrome?

Causes of Zollinger-Ellison syndrome: see causes of Zollinger-Ellison syndrome
Causes of Zollinger-Ellison syndrome: What causes people with Zollinger-Ellison syndrome to develop tumors is unknown, but the cause may be an abnormal tumor suppressor gene. (Source: excerpt from Zollinger-Ellison Syndrome: NIDDK)

What are the symptoms of Zollinger-Ellison syndrome?

Symptoms of Zollinger-Ellison syndrome: see symptoms of Zollinger-Ellison syndrome

Complications of Zollinger-Ellison syndrome: see complications of Zollinger-Ellison syndrome

Can anyone else get Zollinger-Ellison syndrome?

Contagion of cancer: generally not; see details in contagion of cancer.

Zollinger-Ellison syndrome: Testing

Diagnostic testing: see tests for Zollinger-Ellison syndrome.

Misdiagnosis: see misdiagnosis and Zollinger-Ellison syndrome.

How is it treated?

Treatments for Zollinger-Ellison syndrome: see treatments for Zollinger-Ellison syndrome
Research for Zollinger-Ellison syndrome: see research for Zollinger-Ellison syndrome

Organs Affected by Zollinger-Ellison syndrome:

Organs and body systems related to Zollinger-Ellison syndrome include:

Name and Aliases of Zollinger-Ellison syndrome

Main name of condition: Zollinger-Ellison syndrome

Class of Condition for Zollinger-Ellison syndrome: cancer

Other names or spellings for Zollinger-Ellison syndrome:

ZES, gastrinoma, pancreatid ulcerogenic tumor syndrome, partial multiple endocrine adenomatosis

Gastrinoma Source - Diseases Database

Zollinger-Ellison syndrome
Source - WordNet 2.1

MEN 1, Multiple endocrine adenomatosis, Multiple endocrine neoplasia, Wermer syndrome
Source - Office of Rare Diseases (ORD) of the National Institutes of Health (NIH)

Zollinger-Ellison syndrome: Related Conditions

Research the causes of these diseases that are similar to, or related to, Zollinger-Ellison syndrome:


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